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Sine Mandrup Bertozzi

Analytical Chemistry Facility
Senior Technician
Analytical Chemistry
Research center

I hold a Master Degree in Chemical Engineering (2000) from the Department of Organic Chemistry at the Technical University of Denmark - DTU (Denmark). I have a background in the pharmaceutical industry, where I have been working as a synthetic organic/medicinal chemist in Early Drug Discovery at Novartis Pharma (Switzerland) and ACADIA Pharmaceuticals (Denmark), and also in R&D at PolyPeptide Laboratories (Denmark). In 2005, I embarked on a career in the analytical chemistry field providing support to the medicinal chemistry in early drug discovery projects at ACADIA Pharmaceuticals (Sweden). In 2010, I joined IIT as a Senior Technician in the Drug Discovery and Development (D3) Department, where I have been part of setting up the analytical chemistry and biochemistry lab. Within the Analytical Chemistry Facility, I am responsible for in vitro DMPK profiling, chemical characterization and purification of compounds for research projects within IIT and external collaborations. I have co-authored 33 publications in peer-reviewed journals.


Title: M.Sc. in Chemical Engineering
Institute: Technical University of Denmark (DTU)
Location: Kgs. Lyngby
Country: Denmark
From: 1993 To: 2000

All Publications
Montani C., Galbusera A., D'Epifanio B., Ghirardini E., Cornuti S., Pasquin Mariani J.R., De Guzman E., Mandrup Bertozzi S., Armirotti A., Baroncelli L., Gozzi A.
Connectomic and behavioral alterations in creatine transporter deficiency are partially normalized by gene therapy
Article E-print Archive
Ciobanu D.Z., Liessi N., Tomati V., Capurro V., Bertozzi S.M., Summa M., Bertorelli R., Loberto N., Dobi D., Aureli M., Nobbio L., Bandiera T., Pedemonte N., Bassi R., Armirotti A.
Tezacaftor is a direct inhibitor of sphingolipid delta-4 desaturase enzyme (DEGS)
Journal of Cystic Fibrosis
Article Journal
Brindani N., Vuong L.M., Acquistapace I.M., La Serra M.A., Ortega J.A., Veronesi M., Bertozzi S.M., Summa M., Girotto S., Bertorelli R., Armirotti A., Ganesan A.K., De Vivo M.
Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer
Journal of Medicinal Chemistry, vol. 66, (no. 8), pp. 5981-6001
Basagni F., Ortega J.A., Bertozzi S.M., Armirotti A., Summa M., Bertorelli R., Bartolini M., Mellor I.R., Bedeschi M., Bottegoni G., Lembo V., Minarini A., Cavalli A., Rosini M.
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties
European Journal of Medicinal Chemistry, vol. 261
Bellina F., Berti F., Bertozzi S. M., Bandiera T., Bertozzi F.
Highly diastereoselective Heck-Matsuda reaction with pyrazolyl diazonium salts
New Journal of Chemistry
Article in Press Journal